Which statement best describes the onset and course of rheumatoid arthritis?

The statement that rheumatoid arthritis has periods of exacerbation and remission accurately captures the typical course of the disease. Rheumatoid arthritis is characterized by its unpredictable nature, where individuals may experience flare-ups of inflammation and pain, followed by periods where symptoms subside significantly or even disappear entirely. This ebb and flow can vary in duration and intensity from person to person, making it crucial for those affected to understand and manage their condition effectively.

In contrast, the other statements present a more limited or skewed understanding of rheumatoid arthritis. For instance, while the condition can be progressive for some individuals, it does not constantly worsen for everyone; many people experience both improvement and deterioration over time. The notion that rheumatoid arthritis primarily affects older adults after the age of 70 overlooks the fact that it can begin at any age, often starting between the ages of 30 and 60. Lastly, characterizing rheumatoid arthritis as mostly asymptomatic ignores the prevalent symptoms of joint inflammation and pain that define the disease for many individuals. Thus, the statement regarding exacerbation and remission provides a comprehensive insight into the disease's patterns and helps in understanding its management.