Which factor increases the risk of developing rheumatoid arthritis?

Smoking is recognized as a significant modifiable risk factor for developing rheumatoid arthritis. Research indicates that the chemicals found in tobacco can trigger systemic inflammatory responses and may lead to an autoimmune reaction. Smokers are at a higher risk due to the effects smoking has on the immune system, potentially initiating or exacerbating conditions like rheumatoid arthritis. In individuals who are genetically predisposed to rheumatoid arthritis, smoking can further influence the development and severity of the disease.

In contrast, regular exercise, a healthy diet, and frequent hydration are associated with reducing inflammation and promoting overall joint health. These lifestyle choices are typically beneficial and can help lower the risk of developing various chronic conditions, including rheumatoid arthritis. Therefore, they do not contribute to increasing the risk.