What is a common side effect associated with non-steroidal anti-inflammatory drugs?

Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used to relieve pain, reduce inflammation, and lower fever. One well-known side effect associated with the use of NSAIDs is gastritis, which refers to inflammation of the stomach lining. This occurs because NSAIDs can interfere with the production of prostaglandins, which are compounds that help protect the stomach lining. The reduction of these protective factors can lead to irritation of the stomach, causing symptoms such as nausea, vomiting, and abdominal discomfort.

Gastritis can potentially lead to more serious complications, including ulcers or gastrointestinal bleeding, particularly with long-term use of NSAIDs. This highlights the importance of monitoring and managing any gastrointestinal symptoms in patients who are prescribed NSAIDs.

The other choices may not be direct side effects of NSAIDs. While joint stiffness can occur in various conditions, it isn't a side effect of NSAIDs themselves. A skin rash can be a possible reaction but is less common and not characteristic of the typical side effects associated with this class of medications. Weight loss is also not a typical or common side effect of NSAIDs. Therefore, gastritis stands out as the most relevant and common side effect linked to the use of non-steroidal anti-inflammatory drugs.